Mrs.Cardiology, Beneficial Effects of Antioxidants on Biochemistry of Aging
Mrs. Cardiology–Heart Tips Not Tricks (Listen Here) Host: MrsCardiology – firstname.lastname@example.org Episode: Mrs.Cardiology, Beneficial Effects of Antioxidants on Biochemistry of Aging Someone once said, getting old is not for the faint of heart. From menopause to Parkinsons Disease, basic cellular changes and arteriosclerosis, antioxidants can literally be a life safer and there is evidence to prove it. Information today from the from US National Library of Medicine National Institutes of Health. Also a guest case study who found antioxidants helpful for both menopause and an injury sustained after menopause. Listen in to here the Beneficial Effects of Antioxidants on the Biochemistry of Aging.
And Interpreted in plain English by Mrs. Cardiology
The biochemistry of aging.
Department of Pathology, University of Utah School of Medicine, Salt Lake City, USA.
Although philosophers and scientists have long been interested in the aging process, general interest in this fascinating and highly important topic was minimal before the 1960s. In recent decades, however, interest in aging has greatly accelerated, not only since the elderly form an ever-increasing percentage of the population, but because they utilize a significant proportion of the national expenditures. In addition, many people have come to the realization that one can now lead a very happy, active, and productive life well beyond the usual retirement age.
Mrs. Cardiology Interpretation: Baby boomers who are living longer are demanding ways to increase their quality of life and stay healthy.
Scientifically, aging is an extremely complex, multifactorial process, and numerous aging theories have been proposed; the most important of these are probably the genomic and free radical theories. Although it is abundantly clear that our genes influence aging and longevity, exactly how this takes place on a chemical level is only partially understood. For example, what kinds of genes are these, and what proteins do they control?
Mrs. Cardiology Note: Free radicals were discussed extensively and the damage they do on the previous show.
Certainly they include, among others, those that regulate the processes of somatic maintenance and repair, such as the stress-response systems. The accelerated aging syndromes (i.e., Hutchinson-Gilford, Werner’s, and Down’s syndromes) are genetically controlled, and studies of them have decidedly increased our understanding of aging. In addition, C. elegans and D. melanogaster are important systems for studying aging. This is especially true for the former, in which the age-1 mutant has been shown to greatly increase the life span over the wild-type strain. This genetic mutation results in increased activities of the antioxidative enzymes,
Mrs. Cardiology Note: Here begins the case for eating your vegetables and taking your supplements.
Cu-Zn superoxide dismutase and catalase. Thus, the genomic and free radical theories are closely linked. In addition, trisomy 21 (Down’s syndrome) is characterized by a significantly shortened life span; it is also plagued by increased oxidative stress which results in various free radical-related disturbances. Exactly how this extra chromosome results in an increased production of reactive oxygen species is, however, only partially understood. There is considerable additional indirect evidence supporting the free radical theory of aging.
Mrs. Cardiology Note: Free radicals cause advanced aging. Antioxidants fight free radicals.
Not only are several major age-associated diseases clearly affected by increased oxidative stress (atherosclerosis, cancer, etc.), but the fact that there are numerous natural protective mechanisms to prevent oxyradical-induced cellular damage speaks loudly that this theory has a key role in aging [the presence of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, among others; various important intrinsic (uric acid, bilirubin, -SH proteins, glutathione, etc.) and extrinsic (vitamins C, E, carotenoids, flavonoids, etc.) antioxidants; and metal chelating proteins to prevent Fenton and Haber-Weiss chemistry]. In addition, a major part of the free radical theory involves the damaging role of reactive oxygen species and various toxins on mitochondria.
Mrs. Cardiology Note: The damaging role of free radicals to reactive oxygen can be combatted by anti-oxidants so don’t get scared.
These lead to numerous mitochondrial DNA mutations which result in a progressive reduction in energy output, significantly below that needed in body tissues. This can result in various signs of aging, such as loss of memory, hearing, vision, and stamina. Oxidative stress also inactivates critical enzymes and other proteins. In addition to these factors, caloric restriction is the only known method that increases the life span of rodents; studies currently underway suggest that this also applies to primates, and presumably to humans. Certainly, oxidative stress plays an important role here, although other, as yet unknown, factors are also presumably involved.
Mrs. Cardiology Note: To protect your home you would get a security system. In this case to protect yourself against the various effects of aging, EAT YOUR VEGETABLES AND TAKE YOUR ANTIOXIDANT SUPPLEMENTS.
Menopause: a review on the role of oxygen stress and favorable effects of dietary antioxidants.
Department of Biotechnology, University of Alicante, San Vicente, Ap. 99, E-03080 Alicante, Spain.
Menopause is often accompanied by hot flashes and degenerative processes such as arteriosclerosis and atrophic changes of the skin that suggest an acceleration of aging triggered by estrogen lack. Therefore, hormone replacement therapy (HRT) has been considered the most suitable treatment for the above symptoms and processes. However, because of the possible serious side effects of HRT (especially the increased risk of thrombo-embolic accidents and breast cancer) there is a growing demand for alternative treatments of the symptoms and pathological processes associated with menopause. In agreement with the above, we review research that supports the concept that oxygen stress contributes to menopause and that some of its physiopathological effects may be prevented and/or treated improving the antioxidant defense of menopausic and postmenopausic women.
Mrs. Cardiology Note: Listen to Tamar Cerafici’s Case Study to discover what testing and alternatives she has been through that have worked much better for her than the traditional hormone therapy and that therapy included anti-oxidant supplementation.
Accordingly, a selection of micronutrients may be useful as a dietary supplement for protection against the decline of physiological functions caused by age-related oxygen stress. Since aging is accompanied by a progressive oxidation of the physiological sulfur pool, we emphasize the role of the vitamins B that help to maintain the GSH/GSSG ratio in its normal reduced state. Nutritional supplements should also include the key antioxidant vitamins C and E, as well as beta-carotene and the mineral micronutrients found in the oxygen radical-detoxifying enzymes glutathione peroxidase and superoxide dismutase. Moreover, the reviewed data suport the concept that other antioxidants such as lipoic acid and the precursors of glutathione thioproline (TP) and l-2-oxothiazolidine-4-carboxylic acid (OTC), as well as the soy isoflavones and the “coantioxidants” of an hydroalcoholic extract of Curcuma longa may help to prevent antioxidant deficiency with resulting protection of mitochondria against premature oxidative damage with loss of ATP synthesis and especialized cellular functions. Therefore, the administration under medical advice of synergistic combinations of some of the above mentioned antioxidants in the diet as well as topically (for skin protection) may have favorable effects on the health and quality of life of women, especially of those who cannot be treated with HR, suffer high levels of oxygen stress, and do not consume a healthy diet that includes five daily rations of fresh fruit and vegetables.
Mrs. Cardiology Note: When menopause symptoms begin and your doctor suggests hormone therapy please strongly suggest to him that you would prefer to go the route of anti-oxidant therapy.
Can antioxidant diet supplementation protect against age-related mitochondrial damage?
Department of Biotechnology, University of Alicante, E-03080 Alicante, Spain.
Harman’s free radical theory of aging and our electron-microscopic finding of an age-related mitochondrial degeneration in the somatic tissues of the insect Drosophila melanogaster as well as in the fixed postmitotic Leydig and Sertoli cells of the mouse testis led us to propose a mitochondrial theory of aging, according to which metazoan senescence may be linked to oxygen stress-injury to the genome and membranes of the mitochondria of somatic differentiated cells. These concepts attract a great deal of attention, since, according to recent work, the mitochondrial damage caused by reactive oxygen species (ROS) and concomitant decline in ATP synthesis seem to play a key role not only in aging, but also in the fundamental cellular process of apoptosis.
Mrs. Cardiology Note: Cells deteriorate because of the affects of free radicals. Cell deterioration causes aging. So we need to address any anti-aging technologies at the cellular level.
Although diet supplementation with antioxidants has not been able to increase consistently the species-characteristic maximum life span, it results in significant extension of the mean life span of laboratory animals. Moreover, diets containing high levels of antioxidants such as vitamins C and E seem able to reduce the risk of suffering age-related immune dysfunctions and arteriosclerosis. Presently, the focus of age-related antioxidant research is on compounds, such as deprenyl, coenzyme Q10, alpha-lipoic acid, and the glutathione-precursors thioproline and N-acetylcysteine, which may be able to neutralize the ROS at their sites of production in the mitochondria. Diet supplementation with these antioxidants may protect the mitochondria against respiration-linked oxygen stress, with preservation of the genomic and structural integrity of these energy-producing organelles and concomitant increase in functional life span.
Mrs. Cardiology Note: All supplements are not created equal. Remember that you get what you pay for. 32 years of experience in searching for the answer to good health, I have my favorite products as we witness and live with good results! My first step is to get tested with the Pharmanex Bio-Photonic Scanner. This scanner gives you an antioxidant score between 0 and 100,000. The higher your score, the less disease process in your body! So get a baseline on your cellular health. Dr. Oz used this device on his show to test himself and the audience. Watch here! This is the best place to start your journey back to good health and stay on track. You can listen to our show on the Pharmanex Scanner here.
Disclaimer: Companies mentioned on this blog have products that produce results for my family, friends and I.
J Neurol Sci. 2005 Jun 15;233(1-2):145-62.
Listen to the Case study of guest Tamar Cerafici
Who Tamar Is and the Stress of Moving
Stress & menopause
You may think your fixing stress, but if you’re not using antioxidants, your body still thinks it’s starving and will still release cortisol.
Hormones & stress
Don’t be afraid to be your own guinea pig. this means you have to pay attention and keep a record.
(c) Sunita Pandit, Mrs.Cardiology, 2013-2014